
POLYNUCLEOTIDES | SALMON SPERM DNA
A breakthrough injectable biostimulator treatment made of polynucleotides that hydrate, effectively stimulate collagen, firm and contour the skin. The benefits of polynucleotides are hydrating, reducing damage and stimulating collagen production to transform the under-eye or facial area.
Salmon DNA: Polynucleotides treatment price: €225
We offer one of the lowest prices for premium Polynucleotide treatments. The Salmon Sperm Facial is our fastest growing treatment.
Polynucleotide Collagen Booster (Salmon Sperm Treatment)
Polynucleotides, which consist of sterilised Salmon DNA promote deep skin renewal and induce collagen production, providing long lasting rejuvenation.
The benefits they offer are revolutionary, including:
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Skin Regeneration
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Wrinkle Reduction
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Hydration
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Anti-Inflammatory Benefits
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Scar Healing
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The treatment is suitable for your face, undereye chest and hands. Three to four sessions, spaced over 21-28 days are recommended for the best results.
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What are Polynucleotides?
Polynucleotides are derived from purified DNA fragments—often sourced from salmon or trout—are administered to rejuvenate the skin at a cellular level.
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Why choose a Salmon Sperm Treament?
Polynucleotide injectables have become a prominent trend in European aesthetic medicine, celebrated for their regenerative properties that enhance skin quality, stimulate collagen production, and improve elasticity.
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De Gezichtskliniek's Salmon Sperm Facial (Polynucleotide Treatments)​
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Brand Polynucleotides: Nucleofill (beste allround Polynucleotide merk)​
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Target areas: Face including forehead or under eye
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Recommended treatments: 3
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Injector: BIG-registered doctor
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Salmon DNA Treatment
Before the treatment, you will have the opportunity to discuss your goals and the suitability of the treatment. You can ask any questions you may have and the doctor will explain the procedure. You can also decide which areas you want to target. After the area is cleansed, the doctor will inject the polynucleotides superficially into the skin. You will notice some bumps on your skin from the injections. These usually disappear after 24 hours.​
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Best Polynucleotide treatment: locations we serve
Our clinics offering injectable skin treatments such as Polynucleotides are located in Alkmaar, Amsterdam, Hilversum, Eindhoven, Rotterdam, Utrecht and Zwolle.
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Ready to transform your skin? Book online
Book a treatment or consultation online or contact us. We are always here to answer your questions!
Salmon DNA Treatment before and after


Key Benefits of Polynucleotide Treatment (PDRN)
Polynucleotide (PDRN) treatment stimulates collagen, improves skin elasticity, reduces fine lines, deeply hydrates and promotes healing. Ideal for anti-aging, acne scars and overall skin rejuvenation with natural, long-lasting results.
Ideal Candidates for Polynucleotide Skin Boosters
Ideal candidates for polynucleotide skin boosters are people with dull, dehydrated, aging skin, fine lines or acne scars. Suitable for all skin types looking for natural regeneration, improved texture and elasticity. Nucleofill is also suitable for mature skin.
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Polynucleotide Injections Side Effects: How Safe Are They?
Ensuring your safety and delivering effective results is our top priority. Polynucleotides are considered one of the safest skin regeneration treatments available, supported by experts in the field. Polynucleotides are made from highly purified salmon DNA, which has been found to be compatible with human DNA without causing any immune reactions.
Polynucleotides FAQ
What is a salmon sperm facial?
Polynucleotides are an injectable biostimulator made from sterile and purified fragments of fish DNA extracted from salmon or trout sperm, which closely resemble human DNA.
Can polynucleotide treatments help reduce acne scars and uneven skin texture?
Yes, polynucleotide treatments can help reduce acne scars and improve uneven skin texture. Products like Nucleofill, Rejuran S, and Plinest are specifically formulated or used off-label for acne scars and textural improvement.
Are Polynucleotides Safe?
Ensuring your safety and delivering effective results is our top priority. Polynucleotides are considered one of the safest skin regeneration treatments available, supported by experts in the field. Polynucleotides are made from highly purified salmon DNA, which has been found to be compatible with human DNA without causing any immune reactions.
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Do polynucleotides work?
Polynucleotides are known for their fast and visible results. After completing the recommended sessions, you will notice significant improvements in your skin texture, with an impressive 21% improvement. Your complexion will become brighter and wrinkles will be visibly reduced, giving you a more youthful and revitalized appearance.
What areas of the face or body can be treated with polynucleotides?
The most common areas treated are the face including the forehead and under the eys, however, it is also possible to treat the chest or hands with Polynucleotides.
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How is a polynucleotide treatment different from a traditional dermal filler?
Polynucleotide treatments differ from traditional dermal fillers by focusing on skin regeneration rather than volume. They stimulate collagen and elastin production, improving texture, elasticity, and hydration over time. Unlike fillers, which provide instant volume, polynucleotides support long-term skin health and rejuvenation, making them ideal for natural anti-aging results.
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What areas of the face or body can be treated with polynucleotides?
The most common areas treated are the face including the forehead and under the eys, however, it is also possible to treat the chest or hands with Polynucleotides.
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How soon can I see visible results from a polynucleotide treatment?
Visible results from a polynucleotide treatment typically appear within 3 to 4 weeks. Skin becomes smoother, more hydrated, and radiant, with continued improvement in texture and firmness over several months.
What is the recommended number of sessions for optimal polynucleotide results?
For optimal results with polynucleotide (PDRN) treatments, the recommended number of sessions is typically 3 to 4, spaced 2 to 4 weeks apart.
How long do the effects last?
Results typically last from 6 to 12 months. Regular maintenance treatments can help keep your skin looking fresh and rejuvenated. Polynucleotide treatments are a fantastic way to improve skin health and address common concerns such as fine lines, uneven skin tone, and sagging skin.
How much is a polynucleotides treatment?
We offer the lowest price in the Netherlands for Polynucleotides (€225). See our pricelist or deals page for Polynucleotide deals.
Where are you located?
We offer Polynucleotides in all our clinics in Alkmaar, Amsterdam, Eindhoven, Hilversum, Rotterdam, Utrecht and Zwolle. Book a salmon sperm facial online.